@article {85,
	title = {A brief history of human disease genetics.},
	journal = {Nature},
	volume = {577},
	year = {2020},
	month = {2020 01},
	pages = {179-189},
	abstract = {<p>A primary goal of human genetics is to identify DNA sequence variants that influence biomedical traits, particularly those related to the onset and progression of human disease. Over the past 25 years, progress in realizing this objective has been transformed by advances in technology, foundational genomic resources and analytical tools, and by access to vast amounts of genotype and phenotype data. Genetic discoveries have substantially improved~our understanding of the mechanisms responsible for many rare and common diseases and driven development of novel preventative and therapeutic strategies. Medical innovation will increasingly focus on delivering care tailored to individual patterns of genetic predisposition.</p>},
	keywords = {Animals, Genetic Testing, Genetic Variation, Genomics, Genotype, Humans, Phenotype, Rare Diseases},
	issn = {1476-4687},
	doi = {10.1038/s41586-019-1879-7},
	author = {Claussnitzer, Melina and Cho, Judy H and Collins, Rory and Cox, Nancy J and Dermitzakis, Emmanouil T and Hurles, Matthew E and Kathiresan, Sekar and Kenny, Eimear E and Lindgren, Cecilia M and MacArthur, Daniel G and North, Kathryn N and Plon, Sharon E and Rehm, Heidi L and Risch, Neil and Rotimi, Charles N and Shendure, Jay and Soranzo, Nicole and McCarthy, Mark I}
}
@article {61,
	title = {Genetic diversity in populations across Latin America: implications for population and medical genetic studies.},
	journal = {Curr Opin Genet Dev},
	volume = {53},
	year = {2018},
	month = {2018 12},
	pages = {98-104},
	abstract = {<p>Hispanic/Latino (H/L) populations, although linked by culture and aspects of shared history, reflect the complexity of history and migration influencing the Americas. The original settlement by indigenous Americans, followed by postcolonial admixture from multiple continents, has yielded localized genetic patterns. In addition, numerous H/L populations appear to have signatures of pre-colonization and post-colonization bottlenecks, indicating that tens of millions of H/Ls may harbor signatures of founder effects today. Based on both population and medical genetic findings we highlight the extreme differentiation across the Americas, providing evidence for why H/Ls should not be considered a single population in modern human genetics. We highlight the need for additional sampling of understudied H/L groups, and ramifications of these findings for genomic medicine in one-tenth of the world{\textquoteright}s population.</p>},
	keywords = {African Continental Ancestry Group, European Continental Ancestry Group, Genetic Variation, Genetics, Medical, Genetics, Population, Genome, Human, Genomics, Humans, Latin America},
	issn = {1879-0380},
	doi = {10.1016/j.gde.2018.07.006},
	author = {Belbin, Gillian M and Nieves-Col{\'o}n, Maria A and Kenny, Eimear E and Moreno-Estrada, Andres and Gignoux, Christopher R}
}
